CXCR5+ monocyte emigration impairs the radiation-induced antitumor immune response

This mechanistic study illustrates that radiation-associated myeloid responses can also suppress antitumor immunity.

Nature communications · Mar 19, 2026
Original authors: Yutiantian Lei, Rui Jia, Chen Chen, Peihai Cao, Jiahong Shi, Mengdi Huang, Qiuyu Mu, Yixin Wang, Dairu Hou, Mingjun Si, Ruishan Guo, Jiahao Sun, Dingge Jiang, Yihan Wang, Tingting Lv, Ruiying Wang, Junyi Zhang, Du Yang, Hanmin Tang, Jianan Li, Liuyi Yang, Renyi Ding, Wenhua Li, Haiyan Liu, Anjun Jiao, Lingyun Hui, Yanxia Sui, Shan Huang, Mengjiao Cai, Chenchen He, Chen Lin, Fei Wang, Jinlu Ma, Suxia Han, Yuzhu Hou

Related research: included for context and not presented as a PRaG-series trial.

Who was studied?

Experimental models and supporting human sample observations.

What does the publication report?

The authors linked CXCR5-positive monocyte recruitment and GM-CSF-associated macrophage differentiation to radioresistance.

Safety findings

This is not a clinical safety evaluation of PRaG.

How should we interpret it?

Mechanistic findings are context dependent and do not directly establish the benefits or harms of clinical PRaG regimens.

Read the original source

This independently written summary was checked against the publicly available abstract. It is not a translation of the full paper or a clinical recommendation.

CXCR5+ monocyte emigration impairs the radiation-induced antitumor immune response · DOI: 10.1038/s41467-026-70858-6 · PMID: 41857057

Educational reporting, not individualized medical advice. Discuss treatment decisions with your clinical team.