A multicenter, phase II trial of RC48-ADC combined with radiotherapy, PD-1/PD-L1 inhibitor, GM-CSF, and sequential IL-2 (PRaG3.0 regimen) for salvage therapy in patients with HER2-expressing advanced solid tumors.

Who was studied?

32 enrolled patients with HER2-expressing solid tumors; 26 completed tumor assessment.

What does the publication report?

Reported ORR was 38.5%, DCR 69.2% and median PFS 7.2 months.

Safety findings

Grade ≥3 treatment-related events occurred in 2 patients (6.3%).

How should we interpret it?

Conference-level, non-randomized evidence. Linked reports may include the same participants and should not be counted as independent trials.

Read the original source

This independently written summary was checked against the publicly available abstract. Selected figures, where included, are checked against the full publication. This is not a full-paper translation or a clinical recommendation.

A multicenter, phase II trial of RC48-ADC combined with radiotherapy, PD-1/PD-L1 inhibitor, GM-CSF, and sequential IL-2 (PRaG3.0 regimen) for salvage therapy in patients with HER2-expressing advanced solid tumors. · DOI: 10.1200/JCO.2023.41.16_suppl.e14614

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Related publications from the same research program

• Case Report: PRaG 3.0 therapy for advanced cervical cancer with severe comorbidities
• Evaluation of RC48-ADC in Combination with PRaG Regimen: An Open-Label, Prospective, Multicentre Study Assessing Efficacy and Safety for Advanced Refractory HER2-Expressing Solid Tumors (PRaG3.0 Study Protocol)
• An open-label, multicenter, phase II study of RC48-ADC combined with radiotherapy, PD-1/PD-L1 inhibitor sequential GM-CSF and IL-2 for salvage therapy in patients with HER2-expressing advanced solid tumors(PRaG3.0).

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